Almost all sleeping pills, such as Ambien and Lunesta, should be used right before bed. You shouldn't take these Zopisign 10 mg Tablets until you've had a full night's sleep. As a result, the medication must be taken at least seven or eight hours before you wake up.

Take your sleeping prescription after you've slept through the entire night. Only use a sleeping pill if you are positive you will get seven or eight hours of rest without interruption. You can take a few short-acting sleeping pills (such as Zopiclone 10 mg), which are designed to be used during midnight awakenings if you can stay in bed for at least four hours.